Quantum Airlines flight 66 has just taken off from Fankfurt, Germany bound for New York JFK with 247 passengers aboard. After take-off, a man infected with a Doomsday Virus passes out while a flight attendant and Doctor try to save the man. The pilot tries to land the plane but can't because the people on the ground know about the virus. An Ambassodor and his secretary help the pilots struggle through the gov't secret to shoot flight 66 out of the air! And if the plane does land, Doomsday has arrived on earth.