Three women: Cristina (Pilar Punzano), Ana (Silvia Marso), and Rosa (Rosa Mariscal) are sisters who are each dealing with different problems in their love lives. Cristina, the youngest is promiscuous and unable to settle down, Ana, the middle one, feels stifled by a controlling husband and Rosa, the oldest, is a lesbian executive weighed down by ambition.The three sisters. The three sisters, however, find their emotional lives intersecting again when Ana nearly dies after taking too many sleeping pills. Amor, Curiosiad, Prozac y Dudas was based the best-selling novel by Lucia Etxeberria, who also adapted her story for the screen.