WUSS is the story of a high school teacher who faces constant ridicule after he's repeatedly beaten up by several of his own students. Having nowhere else to turn, he eventually teams up with another of his students to fight back. This student, a young girl, is feared school-wide because of a dark family reputation. She also has an unfortunate nickname grafted to her due to her predilection for smoking discarded cigarettes. Bonded in battle, the student and teacher form a friendship that stretches the use of the word inappropriate.