Interweaving love stories centering on real individuals who are utilizing medicine to explore new frontiers of love, sex, and the human form. When the young hermaphrodite Cynthia meets Gen and Jay, a couple recovering from plastic surgery, she learns of Pandrogony, in which two people merge their facial features in order to reflect their evolution from separate identities into one unified entity. Inspired by this, Cynthia abandons her husband and suburban life to embark on a road trip with Gen through the remnants of 20th century America. Simultaneously, a young transman, Syd, meets a young punk man, Nick. After having sex with one another, and someone born of the opposite sex for the first time, Syd and Nick find themselves falling into love, a love that forces them to confront how hormone treatments have forever changed sex and relationships. Not science fiction, but American reality OPEN brings together a cast of real hermaphroditic, pandrogynous, and transpeople to create a revealing look at the pioneers of the new human experience, and the emerging possibilities for humanity at the dawn of a new millennium.