THIS SUMMARY CONTAINS SPOILERS: Lose with English is based around a bizarre inventor of fitness devices by the name of English Jones, which leads him to TV fame and fortune followed quickly by debt and disaster as English's inventions fail, resulting in injuries and poisoning in various catastrophic ways. Failure brings out the usual suspects including debt collectors, the intelligence services and even the Italian mafia as English goes into hiding. The plot thickens as the FBI and Interpol get involved and the mafia attempt to terminate the contract. English meanwhile is holed out incognito, working as a pizza delivery boy in a Pizza takeaway, keeping low and tinkering with his next invention to help rebuild his fortune. The mafia find English and give chase. English cycles off and gets away, resulting in one of the mafia hit men winding up in hospital, but the net is closing in. Under extreme pressure English suddenly invents a new device, which promises to turn his luck around.