"Handle Your Business" is centered on Danielle, a former prostitute and drug addict out of rehab. As she returns to the streets that nearly killed her, she has one goal in mind. Her mission: To take down Bone Daddy, the biggest drug distributor in Brooklyn, and dispose of all the drugs that have been plaguing her community for so long. Danielle may have won her own battle with drugs, but will she be able to save her community from its strong hold?