Based on a true story, "Exit Laughing" is the tale of Ken Resnick, a successful New York businessman who, in his seventies, learns that he has inoperable cancer. With few options available to him, Ken decides to use humor as his secret weapon against the soccer-ball sized tumor growing inside him. Following a long string of visits with various medical specialists, Ken encounters a mysterious spirit, who puts him on a mission that will come to define his existence.