Ang Tanging Ina Mo, Last Na 'To! tells of the wacky yet very emotive story of how the world's most renowed mother INA MONTECILLO (Ai-Ai Delas Alas) spends the remaining days of her life with her best friend Rowena (Eugene Domingo) and her children now that she is dying. When she learns that everyone is facing respective uncontrollable problems, she embarks on a journey of involving herself to their lives an does everything to help them -- only to realize in the end, as every situation gets worse, she has no other option to help them but to face the truth that she is dying and to finally let them go.