Childhood best friends who are both geniuses in school eventually become bittersweet rivals for campus athlete Mark Ferrer. Zoe Tuazon is a rich, overweight and aggressive mestiza, while Aica Tabayoyong is a poor nerdy student with a bad case of teenage acne and nearsightedness. In an effort to outsmart and outclass each other, Zoe and Aica each undergo cosmetic surgery and become ravishing vixens engaged in ugly confrontations.