After a tragic event, which may or may not be her fault, a young woman decides to give it her best and continue trying to live a normal day to day life. Emily Barlow delivers a powerful performance as Melissa, a woman in her early twenties struggling with everyday life while dealing with inner guilt, fear and anger. What Matters Most is a story which demonstrates how family and friends can help one another fight their demons, overcome tragic events, and learn to understand what life is all about.