Kambal Sa Uma tells the story of Ella and Vira, twin sisters who have some of the physical features of a rodent. When she was still a baby, Vira was given away by her mother Milagros and ended up in the care of a rich couple in the city. Meanwhile, Ella remained with her mother and lived in the mountains away from persecution of people. Through a dramatic course of events, Ella and Vira will cross paths and their differences will lead to a bitter clash. What will happen once they discover their real identities? Will love prevail over hate?