Germany in the future: in the EU state, there is a corporation called "Lifecorp" that gives out credit and a payment date. When the creditor cannot pay in time, he is killed and his body recycled. Jan is addicted to gambling, and his debtor gives him one last chance: 400,000 EUR or death. Jan goes to the "Lifecorp" pawn shop, gets the money, pays back - and even wins big in a "last game" with the casino owner. With enough money to repay, he goes back to "Lifecorp" - but the enigmatic Michelle Reuter (Sonja Kirchberger) has other plans, and he discovers his payback time to be expired. Not wanting to give away his body, he runs away; these people not wanting to fulfill their contract are called "Runners" (hence the title) and are hunted by the police as well as Lifecorp.