Headlining the 2012 extravaganza – filmed at London's O2 Arena in aid of Great Ormond Street Hospital – is Jessie J, who opens the show with an exclusive live performance. The all-star line-up also includes Lee Evans, Michael McIntyre, Jonathan Ross, Micky Flanagan, Sean Lock, Kevin Bridges, Jo Brand, Jack Whitehall, Jack Dee, Jon Richardson, Seann Walsh, Lee Nelson, Josh Widdicombe, Paul Chowdhry, Andi Osho, Keith Lemon and Alan Carr.