"Out of Darkness" is about a female Spanish homicide detective named Teresa Maria de los Angeles a.k.a. Angie who works out of a fictional regional police depart in Cleveland, Ohio. She deals with a partner, Detective Drew Avon, who doesn't trust her because Angie's father is an alleged head of a drug cartel. Angie also has two bosses: an overly religious Police Lieutenant and an "ethically challenged" Special Prosecutor who is very friendly with Philip Magnos. Magnos is a businessman who may be behind all the criminal activity in the city. Yet with all that going on, the most disturbing element in Angie's life, is a mysterious shadow like creature that takes over her body and literally devours criminals.