Graduation can't come soon enough in Sophomores: Murphy's Law, where the unfortunate undergraduates of Bardell University explore new schedules, new relationships, and new mysteries. Returning from winter break in different places in their lives, the sophomores are confronted with the unexpected disappearance of one of their classmates and the ongoing investigation it brings onto campus. Meanwhile, transfer student Margeaux Peters sets her focus on her Journalism major, as well as her majorly attractive Journalism T.A., rich girl Lizabeth Martin runs a vicious campaign for sorority presidency, failed musician Luke Jameson returns from a sabbatical in Alaska with a new girlfriend, football star-turned-artist Clive Jenkins pursues his "passion" for art at a rival school, and former drug addict Jackie Copeman returns to Bardell with an entirely new agenda and a new friend named Jesus.