After Viktor Hoza, Joseph Gambino takes the mantle and uses his influence in bringing Cosa Nostra and Red Mafia together to go after Billy Marcello and his team. Marked as Outlaws by the FBI, Billy and his men begin their mission to destroy the organized crime in the country. Joseph Gambino and Billy Marcello face off on a turf battle to the end, each going to the extreme to outdo the other. Money, Power, Friendships and Betrayal form the crux of the changing equations of Mafia in the new century.